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A primary mechanism of curcumin’s modulation of MMP-9 involves inhibition of NF-κB and AP-1 activation, leading to suppressed transcription of MMP-9 mRNA in monocytes, endothelial cells, and cancer models

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The authors suggested the protective effect of vitamin D occurred through the inhibition of a strong proinflammatory response from the host (IFN-γ and TNF-α), mediated directly by its action on Th1 cells, as well as indirectly through the inhibition of innate immunity